Skip to content If you’ve spent any time scrolling through skincare TikToks or deep-diving into anti-aging trends, you’ve probably seen the words “salmon DNA” floating around. At first glance, it sounds more like sushi than skincare. But this high-tech skin treatment, known as Rejuran, is quickly gaining ground as one of the most effective regenerative therapies on the market.
At The Park MedSpa, we’re proud to offer Rejuran as part of our advanced skin rejuvenation lineup—and here’s why everyone’s talking about it.
Rejuran is a polynucleotide (PN)-based injectable treatment derived from salmon DNA. More specifically, it contains PDRN (polydeoxyribonucleotide), a purified DNA extract that has remarkable healing and anti-inflammatory properties. What makes salmon DNA so special? It’s biocompatible with human skin, meaning your body accepts it easily and responds by repairing tissue, boosting hydration, and increasing collagen and elastin production.
The treatment originated in South Korea and has since gained massive popularity throughout Asia before catching fire in the U.S. medical aesthetics scene.
Rejuran is administered through precise microinjections into targeted areas such as the face, neck, or hands. Once introduced into the dermis, the polynucleotides—specifically polydeoxyribonucleotides (PDRN)—initiate a complex cascade of cellular signaling pathways. These molecules bind to specific purinergic receptors on fibroblasts and immune cells, leading to upregulation of growth factors like VEGF (vascular endothelial growth factor) and TGF-β (transforming growth factor-beta). These factors stimulate angiogenesis, enhance fibroblast proliferation, and promote extracellular matrix (ECM) remodeling, including the synthesis of collagen types I and III and elastin fibers.
Additionally, PDRN exhibits anti-inflammatory effects by modulating cytokine activity, reducing oxidative stress, and accelerating the repair of DNA-damaged skin cells. The result is a marked improvement in tissue regeneration, hydration retention, and skin elasticity.
These benefits are progressive—visible improvements typically emerge within 4–6 weeks, with optimal results achieved through a course of 3–4 treatments administered monthly.
It might sound odd to inject fish DNA into your face, but the science is pretty solid. Salmon DNA is packed with nucleotides that promote tissue regeneration and cellular repair. Because salmon DNA closely mirrors the DNA structure in human skin, it helps stimulate fibroblasts (the cells responsible for collagen production) and accelerates natural healing processes.
Here’s why it’s trending:
Rejuran isn’t just a one-trick pony. It’s suitable for a wide range of skin types and concerns:
It’s also a go-to for people looking to prevent skin aging before it becomes more pronounced. Think of it as a regenerative investment in your skin’s future.
Rejuran treatments are quick, typically 30 to 45 minutes. Here’s a breakdown of what to expect:
Because this is a biostimulatory treatment—not a filler—you won’t see immediate volume. Instead, think gradual glow-up over a few weeks as your skin regenerates.
With trendy overfilled cheeks and dramatic transformations, Rejuran offers a natural, refreshed look without adding bulk. It aligns perfectly with the emerging “skin-first” aesthetic philosophy, where the emphasis is on improving skin function, integrity, and radiance rather than altering facial contours.
So, what’s the fuss really about? Rejuran is gaining traction not just for its ability to visibly improve skin texture, but for the scientific credibility behind its ingredients. The polynucleotides in Rejuran don’t merely sit on the skin’s surface—they penetrate deep into the dermis, activating fibroblast activity, enhancing mitochondrial function, and accelerating DNA repair. This goes beyond cosmetic masking; it’s biological skin restoration at the cellular level.
Social media influencers, dermatologists, and beauty editors are all buzzing about it:
Its popularity has been further fueled by celebrity endorsements, trending TikTok testimonials, and a general shift toward evidence-based beauty routines. Whether you’re prepping for a big event or starting a long-term strategy for skin longevity, Rejuran is fast becoming the top choice for anyone serious about regenerative skincare.
At The Park MedSpa, our team goes beyond the needle. Our approach to Rejuran is guided by in-depth consultations, expert injectors, and personalized post-treatment support. We understand that no two skin stories are the same, which is why your Rejuran plan is customized from start to finish.
We also integrate Rejuran into combination protocols when appropriate—like pairing it with microneedling, lasers, or skin tightening—for even better results.
If you’ve been curious about trying Rejuran or are looking for a way to refresh tired, aging, or stressed-out skin, now’s the time. This isn’t just another trend—it’s a science-backed treatment with visible, lasting results.
Book your Rejuran consultation at The Park MedSpa today and experience the regenerative power of salmon DNA for yourself.
Our boutique Spa will offer you a free consultation, a relaxed and unique atmosphere with a fair price structure and the opportunity to benefit from special programs and promotions throughout the year.
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At The Park MedSpa, our team is comprised of highly trained and talented professionals who specialize in providing the utmost care to our clients. Our team is dedicated to providing you with a pleasant experience and exceptional results in your health and wellness.
