Rejuran vs PRP: Which Skin Rejuvenation Treatment Is Best for You?

If you’re looking to revitalize your skin without surgery, you’ve likely come across two powerhouse treatments in the world of regenerative aesthetics: Rejuran and Platelet-Rich Plasma (PRP) therapy. Both promise improved skin texture, boosted collagen, and a natural glow, but they work in different ways, and the right choice depends on your specific skin needs. At The Park MedSpa, we’re here to help you make an informed decision.

Breaking Down the Basics

Rejuran and PRP take very different approaches to skin rejuvenation, so knowing how they work is the first step toward making the right choice for your skin goals.

What Is Rejuran?

Rejuran is an injectable skin rejuvenation treatment derived from polynucleotides (PNs)—molecules extracted from salmon DNA. These PNs promote cell regeneration, improve skin texture, and enhance hydration by repairing the extracellular matrix and stimulating fibroblast activity. Commonly referred to as Rejuran Healer, this treatment is gaining popularity for its ability to restore youthful resilience without altering facial contours.

What Is PRP (Platelet-Rich Plasma)?

PRP therapy involves drawing a small amount of your own blood, processing it in a centrifuge to isolate the platelet-rich plasma, and then injecting it back into the skin. Platelets are packed with growth factors that help regenerate tissues, promote healing, and stimulate collagen production. Often known as the “vampire facial,” PRP is a natural way to rejuvenate skin using the body’s own biology.

How They Work: The Science Behind the Treatments

To make an informed decision between Rejuran and PRP, it helps to look beneath the surface—literally. Each treatment operates through a distinct biological mechanism that triggers skin rejuvenation in different ways. In this section, we’ll explore the science driving their unique effects.

Rejuran: Salmon DNA for Cellular Repair

Rejuran uses polynucleotides to promote tissue repair and reduce inflammation. These molecules:

• Stimulate fibroblast activity for improved collagen and elastin production
• Enhance skin hydration by improving the extracellular matrix
• Support skin barrier function and reduce sensitivity
• Provide antioxidant effects to reduce oxidative stress

PRP: Your Body’s Own Growth Factors

PRP stimulates the skin’s natural healing process through concentrated platelets and their associated growth factors. These components:

• Promote cell regeneration and tissue remodeling
• Encourage angiogenesis for improved circulation
• Trigger collagen synthesis for firmer, smoother skin
• Help heal acne scars and minimize pore appearance

Key Differences at a Glance

Once you understand how Rejuran and PRP work individually, it helps to see how they stack up side by side. This comparison chart breaks down the most important factors—like treatment time, results, and skin concerns addressed—so you can quickly identify which approach better matches your skincare goals.

Feature	Rejuran	PRP
Source	Salmon DNA (Polynucleotides)	Your own blood (platelets)
Mechanism	Stimulates cellular repair and hydration	Triggers healing with growth factors
Treatment Time	~30 minutes	~45-60 minutes (includes blood draw)
Onset of Results	2-4 weeks post-treatment	1-3 months for full effects
Sessions Needed	3-4 sessions recommended	3-6 sessions, depending on concern
Best For	Fine lines, texture, hydration	Acne scars, laxity, dullness
Downtime	Minimal (mild redness)	Mild swelling/bruising possible

When Rejuran May Be the Better Choice

Rejuran is especially effective if you’re dealing with early signs of aging and want to strengthen the skin from within. It’s an excellent option for:

• Refining skin texture and smoothing micro-wrinkles
• Increasing hydration for dry or sensitive skin
• Improving skin barrier health, especially for those with post-inflammatory pigmentation or sensitivity
• Restoring skin elasticity without adding volume or changing contours

At The Park MedSpa, Rejuran is often recommended for patients who seek subtle, long-term rejuvenation with minimal downtime.

When PRP May Be the Better Choice

PRP is a versatile option that excels in stimulating collagen and improving visible skin damage. You may prefer PRP if you are:

• Treating acne scars or post-acne textural issues
• Addressing mild skin laxity or dull, tired-looking skin
• Interested in an autologous, natural treatment with no synthetic ingredients
• Looking to rejuvenate areas like under the eyes or scalp where sensitivity is a concern

Because it leverages your own platelets, PRP is safe and well-tolerated, making it ideal for those looking for regenerative outcomes without adding foreign substances to the skin.

Which Treatment Aligns With Your Skin Goals?

Here’s a more targeted way to decide between Rejuran and PRP:

• Choose Rejuran if your top priorities are hydration, skin barrier repair, and texture refinement. It works well for those with sensitive or maturing skin and is especially helpful for subtle anti-aging.
• Choose PRP if you’re focused on healing and collagen regeneration, particularly for acne scarring, early volume loss, or revitalizing dull skin. It’s a reliable option for those who prefer natural, cell-derived treatments.

Both options offer progressive, cumulative improvements, but they tackle different aspects of skin health. One targets hydration and cellular structure, while the other emphasizes repair and regeneration.

What to Expect at The Park MedSpa

Our team at The Park MedSpa begins every aesthetic journey with a thorough consultation to assess your skin and goals. Whether you choose Rejuran or PRP, you can expect:

• A customized treatment plan based on your skin’s needs
• Expert technique by licensed professionals
• A relaxing, professional environment
• Clear aftercare guidance to optimize results

We aim to make every visit a step toward healthier, more radiant skin.

Choosing the Right Path for Your Skin

Both Rejuran and PRP are backed by scientific research and real-world results. While they share a goal of skin rejuvenation, they achieve it through different pathways.

Rejuran is ideal for enhancing skin quality, hydration, and resilience—perfect for those dealing with early signs of aging or skin sensitivity.

PRP, on the other hand, is a regenerative powerhouse that uses your body’s own growth factors to stimulate collagen, address scars, and refresh tired skin.

Understanding what your skin truly needs is key to making the right choice. If you’re still unsure, the team at The Park MedSpa is here to guide you with honest recommendations tailored to your goals.Book your personalized Rejuran or PRP consultation today and let your skin thrive with the right treatment path.